Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering

نویسندگان

  • Cijun Shuai
  • Yiyuan Cao
  • Chengde Gao
  • Pei Feng
  • Tao Xiao
  • Shuping Peng
چکیده

Bioactive glass (BG) is widely used for bone tissue engineering. However, poor mechanical properties are the major shortcomings. In the study, hydroxyapatite nanowhisker (HANw) was used as a reinforcement to improve the mechanical properties. 63s glass/HANw scaffolds were successfully fabricated by selective laser sintering (SLS). It was found that the optimal compressive strength and fracture toughness were achieved when 10 wt.% HANw was added. This led to 36% increase in compressive strength and 83% increase in fracture toughness, respectively, compared with pure 63s glass scaffolds. Different reinforcement mechanisms were analyzed based on the microstructure investigation. Whisker bridging and whisker pulling-out were efficient in absorbing crack propagating energy, resulting in the improvement of the mechanical properties. Moreover, bioactivity and biocompatibility of the scaffolds were evaluated in vitro. The results showed that composite scaffolds with 10 wt.% HANw exhibited good apatite-forming ability and cellular affinity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hydroxyapatite whisker-reinforced polyetherketoneketone bone ingrowth scaffolds.

Hydroxyapatite (HA) whisker-reinforced polyetherketoneketone (PEKK) bone ingrowth scaffolds were prepared and characterized. High levels of porosity (75-90%) and HA whisker reinforcement (0-40 vol.%) were attained using a powder processing approach to mix the HA whiskers, PEKK powder and a NaCl porogen, followed by compression molding at 350-375 degrees Celsius and particle leaching to remove t...

متن کامل

Cytotoxicity evaluation of 63s bioactive glass and bone-derived hydroxyapatite particles using human bone-marrow stem cells.

BACKGROUND In recent years, bioceramics have been favored by biomaterials scientists and researchers. Due to their special and distinctive features, bioactive glass and hydroxyapatite possess a higher place among different types of bioceramics. METHOD In this study, the effect of 63S bioactive glass and bone-derived hydroxyapatite particles on the proliferation of human bone-marrow stem cells...

متن کامل

Fabrication of Porous Hydroxyapatite-Gelatin Scaffolds Crosslinked by Glutaraldehyde for Bone Tissue Engineering

In this study, to mimic the mineral and organic components of natural bone, hydroxyapatite[HA] and gelatin[GEL] composite scaffolds were prepared using the solvent-casting method combined with a freeze drying process. Glutaraldehyde[GA] was used as a cross linking agent and sodium bisulfite was used as an excess GA discharger. Using this technique, it is possible to produce scaffolds with mecha...

متن کامل

Synthesis and characterization of fiber reinforced polymer scaffolds based on natural fibers and polymer for bone tissue engineering application

A wide range of materials and scaffolding fabrication methods for bone tissue engineering have beenexplored recently. Fiber reinforced polymers (FRP) system appears to be a suitable system. By the exclusiveuse of biocompatible or bio-absorbable polymers and fibers, novel generation of scaffolds for applicationsin tissue engineering can be prepared. Mulberry Silk as highlighted...

متن کامل

Effects of hydroxyapatite reinforcement on the architecture and mechanical properties of freeze-dried collagen scaffolds.

Freeze-dried collagen scaffolds reinforced with hydroxyapatite (HA) are of clinical interest for synthetic bone graft substitutes and tissue engineering scaffolds, but a systematic evaluation of the effects of the HA reinforcement weight fraction and morphology on the mechanical properties is lacking. Therefore, freeze-dried collagen scaffolds were reinforced with either HA whiskers or an equia...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2015  شماره 

صفحات  -

تاریخ انتشار 2015